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divi s laboratories limited (532488) hits 52 week high ✌️【Online Recruitment】✌️ Free stock selection service to help you quickly pick high-return stocks for stable growth. A bold plan to genetically engineer a version of thewoolly mammoth, the tusked ice age giant that disappeared 4,000 years ago, is making some progress, according to the scientists involved.

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divi s laboratories limited (532488) hits 52 week high ✌️【Online Recruitment】✌️ Real-time global stock trend and futures data to help you plan investment strategies for long-term returns. Resurrecting the extinct species has been a pet project of Harvard University geneticist George Church for more than a decade. The plan gained traction in February 2021 when Church cofounded Dallas-based Colossal Biosciences with entrepreneur Ben Lamm and received an infusion of cash and an ensuing glare of publicity later that year.

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Church and Eriona Hysolli, Colossal’s head of biological sciences, revealed they had reprogrammed cells from an Asian elephant, the mammoth’s closest living relative, into an embryonic state — the first timestem cells have been derived from elephant cells. The team plans to publish the work in a scientific journal, but the research hasn’t yet undergone peer review.

divi s laboratories limited (532488) hits 52 week high ✌️【Online Recruitment】✌️ Free stock data analysis to help you select stocks accurately and capture market trends. These modified cells, known as induced pluripotent stem cells or iPSCs, can be further teased in the lab to grow into any kind of elephant cell — an important tool as the researchers model, test and refine the scores of genetic changes they need to make to give an Asian elephant the genetic traits it needs to survive in the Arctic. These include a woolly coat, a layer of insulating fat and smaller ears.

“So what’s beautiful about the cells is they can potentially renew indefinitely and differentiate into any cell type of the body,” said Hysolli, who is the company’s lead scientist on the mammoth project.

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Cellular research techniques pioneered by Colossal have opened up a new avenue for saving the endangered elephant, said Oliver Ryder, director of conservation genetics at the San Diego Zoo Wildlife Alliance.

“The intention to produce iPSCs from elephants has been out there for years. It has been difficult to accomplish,” said Ryder, who was not involved in the research. “The impact on conservation is going to be in the realm of genetic rescue and assisted reproduction,” he added.

For obvious reasons, it’s hard to study naturally occurring elephant embryos. The stem cells would allow scientists to create model elephant embryos that will lift the curtain on how an elephant develops into a fetus — a “very valuable asset,” Ryder said.

divi s laboratories limited (532488) hits 52 week high ✌️【Online Recruitment】✌️ Free global stock market data to help you plan the best investment strategies and seize market opportunities. The elephant stem cells also hold the key to the mammoth’s rebirth. Once edited to have mammoth-like genetic traits, the elephant’s cells could be used to make eggs and sperm and an embryo that could be implanted into some kind of artificial womb. However, that will take years of work.

Given an initialsix-year deadline set by Colossal, the team plans to first employ existing cloning techniques similar to those used in 1996 to makeDolly the sheep, inserting genetically edited cells into a donor egg that would be gestated by a surrogate elephant mom. However, even though that technology has been around for a while, the results are hit and miss. And many question whether it is ethical to useendangered animals as surrogates given the likelihood of failed attempts.

“I think the first engineered elephant will be the major milestone and that may be consistent with Ben’s (Lamm) prediction of six years from 2021,” Church said. “The second thing that will make us happy is we have one that’s really cold resistant. Then the third one will be if we can do it in a way that’s scalable, that doesn’t involve surrogates. That’s an unknown distance out,” Church said.

divi s laboratories limited (532488) hits 52 week high ✌️【Online Recruitment】✌️ Expert predictions with real-time stock, futures, and metals, energy data to help you quickly recover and grow. The research team at Colossal has already analyzed the genomes of 53 woolly mammoths from ancient DNA recovered from fossils. The wide-ranging specimens from animals that lived in different places at different points in the past helped the scientists understand exactly which genes make a mammoth unique.

“We’ve come a long way. Mammoth DNA quality is almost as good as the elephant and both of them are almost as good as (DNA extracted from) humans,” Church said.

Church and Hysolli didn’t say exactly how many genetic changes they expect to make to Asian elephant DNA to make a creature that resembles a mammoth capable of withstanding Arctic temperatures. The geneticists also want to engineer a mammoth with no tusks, so the animals don’t fall prey to poachers.

Church, who has been at the forefront of work togenetically engineer pigswith organs compatible with the human body for transplants, said it is possible to make 69 edits at one time in pigs. The number of modifications needed to make an Asian elephant resistant to the cold would be broadly similar, he said.

Colossal has longed claimed that mammoths, should they return to the grasslands in the planet’s northernmost reaches in sufficient numbers, would help slow down permafrost thaw.

divi s laboratories limited (532488) hits 52 week high ✌️【Online Recruitment】✌️ Real-time India stock and global stock indices, futures prices, and data to help you make efficient investment decisions. Some scientists believe that, before their extinction, grazing animals such as mammoths, horses and bison kept the earth frozen underneath by tramping down the grass, knocking down trees and compacting snow.

Onesmall studyin Siberia published in 2020 suggested that the presence of large mammals such as horses, bison, yak and reindeer resulted in lower soil temperatures in the protected area where they were kept compared with land outside that boundary. However, it’s hard to imagine herds of cold-adapted elephants making a significant impact on a region that’s warming faster than anywhere else in the world,other experts have said.

Colossal also announced plans to resurrect theTasmanian tigerin 2022 and the dodo in 2023, but its work on the mammoth been going on longest.

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