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“We’ve long known that manganese ions and phosphate together make a strong antioxidant, but discovering and understanding the ‘magic’ potency provided by the addition of the third component is a breakthrough. This study has provided the key to understanding why this combination is such a powerful — and promising — radioprotectant,” said study coauthor Brian Hoffman, the Charles E. and Emma H. Morrison Professor of Chemistry and professor of molecular biosciences at Northwestern University’s Weinberg College of Arts and Sciences, in a statement.

Previous research has shown that Deinococcus, known as the most radiant-resistant life-form in theGuinness World Records, can surviveoutside of the International Space Stationfor three years. The hardy bacteria can also withstand acid, cold and dehydration.

Hoffman and Michaely Daly, Uniformed Services University of the Health Sciences professor of pathology, also demonstrated the bacteria’s incredible survivability. The October 2022 report, which the duo coauthored with a team of researchers, showed that if Deinococcus ever existed on Mars, the frozen microbes could havesurvived for millions of years.

For the previous study, the team measured the amount of manganese antioxidants in the cells of the bacteria. The researchers found that the amount of radiation that a microorganism could survive was directly related to its amount of manganese antioxidants. So the more manganese antioxidants present, the more resistance to radiation.

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phoenix overseas limited (phoglobal) stock rallies ✌️【Flexible Income】✌️ Real-time stock and futures data, backed by expert stock market trend predictions, to help you make timely and profitable investment decisions. When dried and frozen, Deinococcus radiodurans could survive 140,000 grays, or units of X-and gamma-ray radiation, which is 28,000 times greater than the amount of radiation that could kill a person.

For the latest research, Hoffman, Daly and their colleagues used MDP, or melatonin-derived protective, a synthetic antioxidant inspired by Deinococcus radiodurans that Daly designed. This antioxidant has been used in radiation-inactivated polyvalent vaccines, which rely on radiation to shut down pathogens like chlamydia. Daly, who has studied Deinococcus radiodurans for years, is also on the National Academies’ Committee on Planetary Protection.

phoenix overseas limited (phoglobal) stock rallies ✌️【Flexible Income】✌️ AI-driven stock trend forecasting with free access to real-time market data, offering personalized investment advice and expert predictions. The study team analyzed how MDP’s active components, including manganese, phosphate and a peptide called DP1, protect cells and proteins from radiation exposure. When the peptide and phosphate bind to manganese, they create a ternary, or triple, complex that is highly effective in protecting against radiation. Together, the metabolites in MDP create a “secret sauce,” Hoffman said.

Dr. Tetyana Milojevic, chair of exobiology at the University of Orléans in France, said the study provides new insights into how radioprotective shields could be created by metabolites, and potentially enhanced in the future. Tetyana was not involved in the study.

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“This new understanding of MDP could lead to the development of even more potent manganese-based antioxidants for applications in health care, industry, defense and space exploration,” Daly said.

Daly noted that astronauts on deep-space missions would be exposed to high levels of radiation, primarily from energetic particles traveling through the cosmos called cosmic rays.

“MDP, being a simple, cost-effective, nontoxic, and highly effective radioprotector, could be administered orally to mitigate these space radiation risks,” he said.

phoenix overseas limited (phoglobal) stock rallies ✌️【Flexible Income】✌️ Free expert predictions on stock trends and real-time data to help you make informed decisions and grow your wealth steadily. Now, the team is curious to see whether this triple complex behind Deinococcus’ antioxidant exists in cells of other organisms, and if so, if they could be responsible for radiation-resistance in them, Hoffman said.

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