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Events like these are good examples of why humans need to finda new place to live, according to proponents of the futuristic idea. Outposts on the moon or Mars could act as an insurance policy against extinction due to catastrophe or self-destruction, they say.

But there’s a lot we don’t know about our ability to survive and thrive in space – including if we can reproduce. Now, freeze-dried mouse sperm, stored aboard the International Space Station (ISS) in a radiation protection box, could help give us a better understanding of mammals’ ability to procreate off Earth.

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Back in his laboratory in Japan, Wakayama is developing a device that will allow astronauts to conduct rodent in vitro fertilization (IVF) aboard the ISS in the coming years. Ultimately, the experiments could help save humankind, he says.

“Our aim is to establish a system for safely and permanently preserving Earth’s genetic resources somewhere in space – whether on the moon or elsewhere – so that life can be revived even if Earth faces catastrophic destruction.”

It may sound straight out of a sci-fi movie, but Wakayama has long been pushing the boundaries with his reproductive studies. In 1997, he and another academic developed a novel method that they used to clone the world’s first mouse from adult cells.

He led a study on the development of mouse embryos in space – something that had previously only been done with creatures like amphibians and fish. And he and his team pioneered a freeze-drying method used to send mouse sperm to the ISS, where it was stored in a freezer for up to six years. When the samples got back to Earth, the researchers rehydrated them and produced healthy baby mice.

From that study, they determined that freeze-dried sperm could stay viable for 200 years in space. Although that’s impressive, Wakayama says it’s “absolutely not long enough for our future.” With his latest space specimens, he’s using a new device to protect sperm stored at room temperature, from radiation, to see if it might be possible to store samples in space indefinitely.

Fordecades,scientists have been launching Earthly creatures into space to study how microgravity and cosmic radiation impact biological processes – including reproduction.

In 1989, for example,32 fertilized chicken eggswere sent into orbit to study how they’d develop without gravity, in an experiment sponsored by the American fast-food chain KFC, and nicknamed “Chix in Space.”

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“We have seen that most of the specific phases of the reproductive cycle can occur in space, at least in a species or two, not always completely successfully,” saidVirginia Wotring, a professor at the International Space University, a private non-profit institution in Strasbourg, France, devoted to space education.

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Humans are a long way from becoming a multi-planet species, but we are making progress. In late 2026, the NASA-led Artemis program will return astronauts to the moon for the first time since 1972, where it hopes to develop an ongoing presence. And if SpaceX founder Elon Musk’s predictions are accurate, the first crewed mission to Mars could be on its wayin the next four years.

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But Wakayama believes his work will be crucial as humans spend more time in space. Damaged DNA in sperm and eggs, for example, could pass genetic abnormalities on to the next generation, he says.

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He adds that the work could be replicated and built upon for other species, which could be helpful for transporting animals like dogs for companionship and livestock like cattle for food, to other planets.

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“In sci-fi movies, people live on other planets and babies are born, but we don’t even know if that’s possible yet,” he says.

He hopes his experiments can help shed light on whether humans can reproduce and develop normally in the harsh environment of space.

“If we can confirm that, it will bring reassurance,” says Wakayama. “And if it doesn’t work, we need to understand how to address that challenge.”

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