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“Driven by curiosity and plausible applications, some researchers had begun work toward creating lifeforms composed entirely of mirror-image biological molecules,” the researchers wrote in a report published December 12 by the journalScience.

“Such mirror organisms would constitute a radical departure from known life, and their creation warrants careful consideration.”

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“It’s a genie you don’t want to let out of the bottle,” said report coauthor Jonathan Jones, a group leader at The Sainsbury Laboratory in Norwich, United Kingdom.

“The risk of something bad happening is low, but the consequences of something bad happening are really awful,” he added.

Unless compelling evidence were to emerge that mirror life would not pose extraordinary dangers, research with the goal of creating mirror bacteria should not be permitted, and funders should make clear that they will not support such work, the scientists recommended.

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Immune systems rely on recognizing specific molecular shapes found in invading bacteria. If these shapes were reflected — as they would be in mirror bacteria — recognition would be impaired and immune defenses could fail, potentially leaving organisms vulnerable to infection.

“We cannot rule out a scenario in which a mirror bacterium acts as an invasive species across many ecosystems, causing pervasive lethal infections in a substantial fraction of plant and animal species, including humans,” the scientists argued in the Science report.

“Even a mirror bacterium with a narrower host range and the ability to invade only a limited set of ecosystems could still cause unprecedented and irreversible harm.”

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“Even if it didn’t grow very well initially, mutations would kick in and there’d be selection for something that grew better. That’s the way evolution works,” Jones explained.

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“Broadly I agree with the concerns, although they are very speculative considering research is currently at a very early stage and a long way from being any threat,” said Ellis, who wasn’t involved in the research.

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“This ‘synthetic cell’ work is challenging enough already when (scientists) use normal molecules, enzymes and chemicals. When they have to do all that but only with mirror molecules, that all need to be made and invented, then it makes it … 1000x harder,” he said via email.

“The scale of difficulty is akin to humans preparing to land on Mars, and people starting to talk about flying to other stars and galaxies,” he said. “There’s such a leap in difference of the achievement needed, and the basic initial goal isn’t even done yet.”

Correction: An earlier version of this story misstated the source of the technical report by Adamala et al. that accompanied the Science article published on December 12.

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