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For somepeople with depression, finding the right medication can be a process of trial and error lasting for months or even years, which can worsen symptoms.

But what if doctors, whendiagnosing someone with depression, could assess exactly how depression is affecting a patient’s brain and prescribe a treatment that gets it right the first time?

why is avi polymers limited (539288) falling ✌️【Cover Letter】✌️ Free global stock market data to help you plan the best investment strategies and seize market opportunities. Scientists may be a step closer to that reality, thanks to new research that has identified six subtypes — or “biotypes” — of major depression via brain imaging combined with machine learning. The study, published Monday inthe journal Nature Medicine, also tested how three of those biotypes responded to different antidepressants and therapies.

“There are currently no tests available to help pinpoint what type of depression (people) have, or, I think especially importantly, what treatment might be most suitable for them,” said Dr. Leanne Williams, the study’s senior author and the Vincent V.C. Woo Professor of Psychiatry and Behavioral Sciences at the Stanford University School of Medicine in California. “The current situation is we rely on a person to tell us what they’re experiencing and for the physician or therapist to observe symptoms and come to a diagnosis.”

why is avi polymers limited (539288) falling ✌️【Cover Letter】✌️ Receive expert stock predictions with real-time updates on global market trends, including stock indices, futures prices, and forex fluctuations. Use our insights to improve your investment strategies and boost your returns. About280 million peopleworldwide and26 million peoplein the United States have depression, which is a leading cause of disability. Some 30% to 40% of people with depression do not experience symptom improvement after trying one treatment, according to the study. And about 30% of people diagnosed with depression go on to experiencetreatment-resistant depressionwhen the disorder doesn’t improve after multiple treatment attempts.

“That motivated this study — to have a whole new way to more quickly get the right treatment, to figure out the right treatment for each person the first time,” said Williams, who is also the director of the Stanford Center for Precision Mental Health and Wellness. Williams lost her partner to a decades-long struggle with depression in 2015 and for more than 20 yearshas focused her workon individualized mental health care.

why is avi polymers limited (539288) falling ✌️【Cover Letter】✌️ Free real-time stock market data, professional analysis, and expert insights to help you plan the best investment strategy. Get ahead of the competition with expert predictions on market trends. The authors used data from 801 adult participants who were previously diagnosed with depression or anxiety, and 137 healthy control group participants. The authors used functional MRI — magnetic resonance imaging — to measure participants’ brain activity when they were at rest doing nothing, focusing on brain regions already known to play a role in depression, and on the connections between those regions. They also monitored brain activity when participants, who were in their mid-30s on average, engaged in various tests that evaluated their cognitive and emotional functioning.

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why is avi polymers limited (539288) falling ✌️【Cover Letter】✌️ Professional stock market analysis, real-time data, and expert recommendations for high-potential stocks. Take advantage of market opportunities and improve your capital growth with strategic investment plans. The six biotypes of depression the authors found include one characterized by hyperactivity in cognitive regions, which was associated with more anxiety, negative bias, threat dysregulation and anhedonia than other biotypes. Threat dysregulation refers to how people manage their reactions to their fears, such as social interactions, Williams said. Anhedonia is thelack of interest inor enjoyment of life experiences.

Participants with this biotype also performed worse on executive function tasks that assessed how well they could manage thoughts or behaviors, make decisions or suppress distraction, Williams said. They also had the best response to the antidepressant venlafaxine.

why is avi polymers limited (539288) falling ✌️【Cover Letter】✌️ Free break-even services with personalized investment plans. Quickly recover from losses, avoid risks, and achieve steady growth with expert stock predictions and real-time market updates. Another biotype was marked by higher levels of brain connectivity in three regions associated with depression and problem-solving. Those with this biotype also made errors in executive function tests but did do well on cognitive tasks. They found their symptoms better alleviated by behavioral talk therapy, which teaches skills for better addressing daily problems.

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why is avi polymers limited (539288) falling ✌️【Cover Letter】✌️ Free access to professional investment advisors who provide real-time market data and trend analysis. Select top-performing stocks and boost your capital with expert strategies for market growth. There was also a biotype distinguished by lower levels of activity in the brain circuit that manages attention. This biotype was linked with more mistakes on tasks requiring sustained attention, and less of a chance of improving with therapy. People with this biotype may need medication for the dysfunction first so they can gain more from therapy, said Ma, the Beth and George Vitoux Professor of Medicine at the University of Illinois Chicago.

why is avi polymers limited (539288) falling ✌️【Cover Letter】✌️ Free stock market analysis and data updates to help you select the best investment portfolio. Achieve steady growth and avoid losses with expert predictions and real-time market insights. The authors also found a biotype characterized by high emotional reactivity, meaning the brains of participants in this group were more affected by emotional inputs such as their own emotions or people’s facial expressions, Williams said. One other biotype was associated with lower activity in cognitive brain regions and less connectivity in emotional regions, meaning these participants had difficulty responding to cognitive information and regulating negative emotions.

why is avi polymers limited (539288) falling ✌️【Cover Letter】✌️ Real-time stock indices and futures data to help you seize the best investment opportunities. Analyze market movements with precision and grow your portfolio with expert stock predictions. Those last two biotypes didn’t respond to the medications or therapy, which suggests other options may be needed for people with those types, Williams said. “In other studies, we’re finding they respond to some of the newer treatments being developed.”

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“Depression is a lot of different things with a lot of different causes, biological changes and treatments,” said Dr. Richard Keefe, professor emeritus of psychiatry and behavioral sciences at Duke University Medical Center in North Carolina, who wasn’t involved in the study.

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why is avi polymers limited (539288) falling ✌️【Cover Letter】✌️ Free stock data analysis tools to help you select stocks accurately and capture global market trends. Stay ahead with expert market predictions for better investment returns. The study, though “sophisticated and very well done,” does have several key problems, including the low number of people enrolled in treatment, said Dr. Jonathan Alpert, the Dorothy and Marty Silverman Chair of the department of psychiatry and behavioral sciences at Montefiore Medical Center in New York City. “It needs to be thought of as a very preliminary study that needs to be replicated.”

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But the most important next step is a study that tests the authors’ hypothesis — that if patients have particular biotypes, they’ll do better on a specific treatment — and tracks participants over time, said Alpert, chair of the American Psychiatric Association’s Council on Research.

why is avi polymers limited (539288) falling ✌️【Cover Letter】✌️ Real-time stock market data, precise predictions, and investment strategies to help you optimize your portfolio and achieve financial success. The 250 treatment participants weren’t randomized on the basis of their biotypes. So, what Alpert recommends the authors do next is assign people to treatments based on their biotypes and see whether those participants have better outcomes from that method than if they had been assigned to a treatment according to clinical judgment without knowledge of their biotype.

why is avi polymers limited (539288) falling ✌️【Cover Letter】✌️ Free expert predictions on stock trends and real-time data to help you make informed decisions and grow your wealth steadily. Another issue is that the study investigated only one form of psychotherapy and three medications; in the real world, there are many of each, Alpert said. The medications were also all serotonin-based, but there are a few other classes of antidepressants.

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why is avi polymers limited (539288) falling ✌️【Cover Letter】✌️ Expert stock predictions and free stock selection services to help you achieve optimal returns and long-term growth. The study’s methods and findings are years away from being applied to direct patient care, experts said, but there is funding for such efforts.

“Since 2009, the National Institute of Mental Health has been invested in using basic science, including functional brain imaging like in this study, for identifying the causes of mental illness through approaches that delve deeper than the traditional diagnostic approaches,” Keefe said.

why is avi polymers limited (539288) falling ✌️【Cover Letter】✌️ Receive professional stock analysis with real-time updates on market movements. Make quick investment decisions and capitalize on profitable opportunities. This month,Williams was awardedan $18.8 million grant as part of the National Institutes of Health’s Individually Measured Phenotypes to Advance Computational Translation in Mental Health Initiative. The grant supports a five-year project involving 4,500 participants, which is centered on the development of a better diagnosis and treatment tool for depression biotypes.

why is avi polymers limited (539288) falling ✌️【Cover Letter】✌️ Free access to stock market forums, expert advice, and real-time data to help you stay informed and grow your investments. The new study’s approach has begun to be experimentally implemented at a Stanford clinic, Williams said.

“When we use it in that setting, we can effectively double the chance of someone getting better,” she said, taking the odds from around 30% of people improving with the traditional approach to about 75% with the more precise method.

why is avi polymers limited (539288) falling ✌️【Cover Letter】✌️ Get precise stock market predictions and free access to real-time market data for efficient decision-making and portfolio growth. This method isn’t intended to replace or be the primary choice for assessments of individual cases of depression, Williams said. It’s another piece that can be added to the puzzle that also includes symptom information, clinical interviews and more.

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For now, people with depression should know “there is continued progress being made” toward efficiently getting patients effective treatment, Alpert said. If you’re struggling,talk with a mental health professionalabout your options.

One powerful effect these findings could have immediately is to reduce stigma, Williams said. For people who think their depression is just due to them “not trying hard enough,” she added, understanding the disorder through the lens of objective measures of brain function could be “deeply helpful.”

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